Brand Name : Cosate
Generic Name : Colistimethate Sodium for Injection IP
Pack Size : vial
Dosage Form : Lyophilized Powder for Injection
Strength : 1 MIU, 2 MIU, 3 MIU & 4.5 MIU
Therapeutic indications : Colistimethate by intravenous administration is indicated in adults and children including neonates for the treatment of serious infections due to selected aerobic Gram-negative pathogens in patients with limited treatment options. Colistimethate by inhalation is also indicated for the management of adult and paediatric chronic pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis. Consideration should be given to official guidance on the appropriate use of antibacterial agents.
Pharmacotherapeutic group : Antibacterials for systemic use, other antibacterials, polymyxins
ATC code : J01XB01
Pharmacodynamic properties : Colistin is a cyclic polypeptide antibacterial agent belonging to the polymyxin group. Polymyxins work by damaging the cell membrane and the resulting physiological effects are lethal to the bacterium. Polymyxins are selective for aerobic Gram-negative bacteria that have a hydrophobic outer membrane.
February 12, 2022